Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer​

Publishing house: International Journal of Hyperthermia
Main author: Cihan Gani
Other authors: Y. Harima, K. NagataA, K. Harima, V. V. Ostapenko, Y. Tanaka, S. Sawada
Date: 2016-07-17

DOI: 10.3109/02656736.2015.1117661

Language: english

Publication class: Retrospective study

Randomized: No

Number of patients: 103

Description of HT type: Local HT, deep, radio waves

Device: BSD-2000/3D

Disease entity: Locally advanced rectal cancer

Symbol of disease entity: LARC

Stage: II-III

Types of combination with HT: HT+RT+CT

CT type: 5-Fluorouracil

Abstract: Purpose: The aim of this study was to evaluate the impact of deep regional hyperthermia on long-term local control and survival in locally advanced non-metastatic rectal cancer.
Methods: In total 103 patients with locally advanced non-metastatic rectal cancer were treated preoperatively with either neoadjuvant radiochemotherapy alone (n¼43) or the same treatment with additional deep regional hyperthermia (n¼60). The two groups were compared with respect to local control, overall survival (OS), disease-free survival (DFS), and distant metastases-free survival (DMFS).
Results: Patients receiving additional hyperthermia had excellent long-term local control with a 5-year Kaplan-Meier estimate of 98% compared with 87% in the radiochemotherapy only group (p¼0.09). Five-year rates for OS (88% versus 76%, p¼0.08), DFS (77% versus 73%, p¼n.s.) and DMFS (75% versus 77%, p¼n.s.) were not statistically different between the two groups.
Conclusion: Radiochemotherapy combined with hyperthermia results in excellent long-term local control.

Need more information about the article? Please contact with PTHO by email.